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Modeling

Nova's approach to Model-Informed Drug Development (MIDD), from what a model is to what a simulation can decide.

Part 9. Conclusions

Baruch Spinoza wrote "demonstrations are the eyes of the mind"\[1\]. By demonstration he meant something close to rigorous reasoning. Add "validated", making it rigorous and validated reasoning, and the aphorism, which was also the rule of his own life, can be read as: models are the eyes of the mind. Everything above makes that version acceptable, at least intuitively. Our eyes and our brain transmit to our mind models of reality that help us understand it and act on it. This document set out to justify that aphorism in therapeutic research, and to show how to put it into practice.