📄️ NOVA’s approach to Model Informed Drug Development
##### Jules Henri Poincaré (French mathematician, 1854-1912)
📄️ Part 1. Introductory remarks
##### TL; DR
📄️ Part 2. NOVA’s approach reconciles knowledge with data to predict clinical outcomes
##### TL; DR
📄️ Part 3. NOVA’s Modeling and Simulation approach
##### TL; DR
📄️ Part 4. Responders - the M&S perspective
##### TL; DR
📄️ Part 5. Examples of Effect Model applications
##### TL; DR
📄️ Part 6. Are M&S outputs real?
##### TL; DR
📄️ Part 7. What can NOVA’s approach be used for?
##### TL; DR
📄️ Part 8. Expected consequences on R&D and future of MIDD
##### TL; DR
📄️ Part 9. Conclusions
Baruch Spinoza wrote “demonstrations are the eyes of the mind"\[1\]. By demonstration he meant something like “rigorous reasoning”. If we add “validated”, turning the definition into “rigorous and validated reasoning'', the philosopher aphorism (and rule of his own life) can be read: “models are the eyes of the mind". All the derivations above make this new version acceptable, at least intuitively. Our eyes associated with our brain transmit to our mind models of reality that help us to understand it and take action. This document was aimed at explaining how to justify and put into practice this aphorism in the field of therapeutic research.